comparison of hydrophilic natural gums and cellulosic polymers in formulation of sustained-release matrix tablets of terbutalin sulfate
نویسندگان
چکیده
the short half-life of terbutaline sulphate (tbs) requires frequent dosing for controlling chronic pulmanary disorders, such as night asthma. the purpose of the present study was to prepare sustained-release (sr) tablets of tbs to decrease the number of doses frequency and to promote the paitent compliances. it was also desirable to evaluate the capability of natural gums for preparation of sr oral dosage forms in comparison with the cellulosic polymers. sr tablets of tbs (7.5 mg) were prepared using either natural gums; guar (g) or xanthan (x) and cellulosic polymers; hydroxypropyl methylcellulose (h) or carboxymethyl cellulose (c) by direct compression method. different ratios of 0:100, 20:80, 40:60, 60:40 of c : h, g : x, x : h or h : g were used. after evaluation of physical characteristics of tablets, release rate were compared with the standard tablets (bricanyl ® sr) in phosphate buffer solution (ph 7.4). all tablets met the official physical properties. tablets with 80:20 ratio of polymers, h 8 x 2 and g 8 x 2 had smaller de 8% (dissolution efficiency) and higher mdt (mean dissolution time) . in the ratio of 60:40 and 40:60 formulations h 4 x 6 and h 6 x 4 had the highest mdt, and the smallets de 8% . formulation h 4 x 6 released the drug with zero-order kinetics while h 6 x 4 followed a higuchi pattern such as standard tablet. it is concluded that formulation containing guar and xanthan (g 8 x 2 ) released the drug with a zero-order kinetic and was the most similar formulation to the standard.
منابع مشابه
Formulation and Evaluation of Sustained Release Matrix Tablets of Glipizide
The purpose of this study was to develop a new monolithic matrix tablet to completely deliver glipizide in a zero order manner over a sustained period. Two approaches were examined using drug in a formulation that contain polymer like hydroxylpropyl methyl-cellulose K 100 (HPMCK) and Eudragit L 100. The granules were prepared by wet granulation method and thereby formulated as F-1, F-2. F...
متن کاملHydrophilic Natural Polymers for Sustained-controlled Release of Calcium Hydroxide
Calcium Hydroxide (CH) is commonly employed as intracanal medicament in endodontics. In order to maximize its therapeutic effects, it is essential to develop new approaches for preparing the controlled drug release systems which, in turn, facilities the dissociation of CH into calcium and hydroxyl ions. This work studies the sustained-controlled release of calcium ions and the effect of pH chan...
متن کاملHydrophilic Natural Polymers for Sustained-controlled Release of Calcium Hydroxide
Calcium Hydroxide (CH) is commonly employed as intracanal medicament in endodontics. In order to maximize its therapeutic effects, it is essential to develop new approaches for preparing the controlled drug release systems which, in turn, facilities the dissociation of CH into calcium and hydroxyl ions. This work studies the sustained-controlled release of calcium ions and the effect of pH chan...
متن کاملFormulation and In Vitro Evaluation of Extended Release Tablets of Paliperidone Using Natural Gums
Paliperidone is a well known dopamine antagonist of the atypical antipsychotic class. In the present study Paliperidone was formulated as ER release tablets using natural and synthetic polymers separately or in combination. The aim of ER release formulation is to reduce the frequency of dosing. Tablets are prepared by direct compression method. The optimized formulations contain Paliperidone as...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
research in pharmaceutical sciencesجلد ۱، شماره ۱، صفحات ۳۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023